MOHAMMAD IZADIFAR THESIS

MOHAMMAD IZADIFAR THESIS

Despite advancements in cardiovascular treatments and interventions, current therapies can only slow down the progression of heart failure, but not tackle the progressive loss of cardiomyocytes after MI. Physics in Medicine and Biology 59 10 , Send us a note and we’ll see what we can do! A generalized diffusion mathematical model taking into account three major particle geometries was developed and coupled with genetic algorithm for determination of effective diffusivity and partition coefficient through an inverse simulation approach. In vivoimaging of rat cortical bone porosity by synchrotron phase contrast micro computed tomography. Dose estimates when electrons strike a copper absorber during injection at the Canadian Light Source. The horizontal packed bed demonstrated a large temperature gradient across the thickness of the bed during RF heating; however, a uniform RF heating was achieved when the vertical packed bed reactor was used for RF-assisted extraction of podophyllotoxin.

To this end, the patches were created from alginate strands using the three-dimensional 3D printing technique and then surgically implanted on rat hearts for the assessment based on phase contrast tomography. Quartersquares, now set to, different weights for grid lines, rectangles or triangles. The effect of solvent dielectric loss factor on uniform RF heating was investigated and the chemical effect of NaCl used for increasing dielectric loss factor of the solvent on podophyllotoxin was assessed. Chemistry and Biology , Also, the limitations of PLGA nanoparticles such as initial burst effect and the lack of time-delayed release patterns are identified. And be sure to sign up for our email newsletter to get the latest free resources and more from Landauer Publishing. Grid paper, divide with light, medium or heavy color grid line.

The bi-layer nanoparticle is composed of protein-encapsulating PLGA core and poly L-lactide PLLA -rate regulating shell, thus allowing for low burst effect, protein structural integrity and time-delayed release patterns. The horizontal packed bed demonstrated a large temperature gradient across the thickness of the bed during RF heating; however, a uniform RF heating was achieved when the vertical packed bed reactor was used for RF-assisted extraction of podophyllotoxin.

Pseudomonas aeruginosa triggers CFTR-mediated airway surface liquid secretion in swine trachea. The first research objective is to optimize nanoparticle-fabrication process in terms of particle size, polydispersity, loading capacity, zeta potential and morphology.

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For this, two models, namely the mechanistic model and geno-mechanistic model, were developed based on the local and global volume averaging approaches, respectively, and then izadfar with experiments on both single- and bi-layer nanoparticles, by which the ovalbumin was used as a protein model for the release examination. Radiation Measurements Journal of the American Ceramic Society 97 7 The other key issue is to non-invasively quantitatively monitor the success of these constructs in-situ, which will be essential for longitudinal assessments as studies are advanced from ex-vivo to animal models and human patients.

One aim of cardiac tissue engineering is to develop implantable constructs e. Metadata Show full item record. And republished without need of permission. Chemistry and Biology Belt and Suspenders, unlock with InApp purchases More paper layouts Hexagon Diagonal quilt Diamond Triangle 8point star to design Lone Stars 6point star More options Unlimited color palettes are fun let you create papers to match school or brand colors Grid Tiling means multiple grids can. Journal of the American Ceramic Society 97 7 International Journal of Paleopathology 6, Send us a note and we’ll see what we can do!

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mohammad izadifar thesis

To achieve this objective, a comprehensive experimental study was performed to examine various process parameters used in the fabrication of poly lactide-co-glycolide PLGA nanoparticles, along with the development thesix a novel computational approach mhoammad the nanoparticle-fabrication optimization.

Physics in Medicine and Biology 60 1 Author Izadifar, Mohammad To achieve this objective, a comprehensive experimental study was performed to examine various process parameters used in the fabrication of poly lactide-co-glycolide PLGA nanoparticles, along with the development of a novel computational approach for the nanoparticle-fabrication optimization. Graph paper for quilters, graph Paper Printables printable quilting quilting tips.

Taken together, this research represents a significant advance in cardiac tissue engineering by developing novel nano-guided approaches for vascularization in myocardium regeneration as well as non-invasive and quantitative monitoring techniques for longitudinal studies on the cardiac patch implanted in animal model and eventually in human patients.

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Author Izadifar, Mohammad Abstract Myocardial infarction MI is the most common cause of heart failure.

Radio Frequency Enhanced Extraction of an Anti-Cancer Compound from Porous Media

Results show that among various process parameters examined, the polymer and the external aqueous phase concentrations are the most significant ones to affect the nanoparticle physical and release characteristics. The bi-layer nanoparticle is composed of protein-encapsulating PLGA core and poly L-lactide PLLA -rate regulating shell, thus allowing for low burst effect, protein structural integrity and time-delayed release patterns.

The third objective is to mohamad novel mathematical models to represent the controlled-release of bioactive agents from nanoparticles. Phase-retrieved images depict visible and quantifiable structural details of the patch at low radiation dose, which, however, are not seen from the images by means of dual absorption-phase and a 3T clinical magnetic resonance imaging.

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The effect of solvent dielectric loss factor on uniform RF heating was investigated and the chemical effect of NaCl used for increasing dielectric loss factor of the solvent on podophyllotoxin was assessed. The second research objective is to develop bi-layer nanoparticles to achieve the controllable release of GFs, meanwhile overcoming the above identified limitations of PLGA nanoparticles. Abstract Myocardial infarction MI is the most common cause of heart failure.

The approach was first verified by reported experimental data of andrographolide extraction followed by determining the effective diffusivity and partition coefficient of podophyllotoxin for different conditions. Development of a bent Laue beam-expanding double-crystal monochromator for biomedical X-ray imaging.

mohammad izadifar thesis

The second research objective is to hhesis bi-layer nanoparticles to achieve the controllable release of GFs, meanwhile overcoming the above identified limitations of PLGA nanoparticles.

The imaging of samples was performed at various sample-to-detector distances, CT-scan time, and areas of the region of interest ROI to examine their effects on imaging quality.